Relationship of Histology to Site in Hodgkin's Disease1

Stanford University Medical Center. The use of consensus findings of a panel of pathologists, in 114 of these cases, has confirmed the applicability and reproducibility of this classification. The pathological findings were correlated with the preoperative clinical evaluation in order to assess the anatomic distribution of lesions. Constancy of the histological pattern in multiple lesions was verified. The nodular sclerosing type was observed in 74% of cases and showed a predilection for the mediastinum (71%) with a high incidence of abdominal involvement (42%). However, the risk of abdominal involvement was greater with mixed cellularity (62%) and lymphocyte predominance (46%) types. Two of 3 patients with lymphocyte depletion had abdominal disease. In striking contrast to the nodular sclerosing type, no patient with lymphocyte predominance showed evidence of mediastinal disease. A high incidence of splenic involvement in patients was noted (42%) including 62% with mixed cellularity, 39% with nodular sclerosis, and 23% with lymphocyte predominance. With the exception of 2 cases of lymphocyte depletion involving the bone marrow and one case of mixed cellular type involving the lung, all other "extranodal" lesions